Cyclometalated Ruthenium(II) Anthraquinone Complexes Exhibit Strong Anticancer Activity in Hypoxic Tumor Cells
Identifieur interne : 000F66 ( Main/Exploration ); précédent : 000F65; suivant : 000F67Cyclometalated Ruthenium(II) Anthraquinone Complexes Exhibit Strong Anticancer Activity in Hypoxic Tumor Cells
Auteurs : Leli Zeng [République populaire de Chine] ; Yu Chen [République populaire de Chine] ; Huaiyi Huang [République populaire de Chine] ; Jinquan Wang [République populaire de Chine] ; Donglei Zhao [République populaire de Chine] ; Liangnian Ji [République populaire de Chine] ; Hui Chao [République populaire de Chine]Source :
- Chemistry – A European Journal [ 0947-6539 ] ; 2015-10-19.
Abstract
Hypoxia is the critical feature of the tumor microenvironment that is known to lead to resistance to many chemotherapeutic drugs. Six novel ruthenium(II) anthraquinone complexes were designed and synthesized; they exhibit similar or superior cytotoxicity compared to cisplatin in hypoxic HeLa, A549, and multidrug‐resistant (A549R) tumor cell lines. Their anticancer activities are related to their lipophilicity and cellular uptake; therefore, these physicochemical properties of the complexes can be changed by modifying the ligands to obtain better anticancer candidates. Complex 1, the most potent member of the series, is highly active against hypoxic HeLa cancer cells (IC50=0.53 μM). This complex likely has 46‐fold better activity than cisplatin (IC50=24.62 μM) in HeLa cells. This complex tends to accumulate in the mitochondria and the nucleus of hypoxic HeLa cells. Further mechanistic studies show that complex 1 induced cell apoptosis during hypoxia through multiple pathways, including those of DNA damage, mitochondrial dysfunction, and the inhibition of DNA replication and HIF‐1α expression, making it an outstanding candidate for further in vivo studies.
Simply the best: The cytotoxicities of RuII complexes are consistent with their hydrophobicity and cellular uptake properties. Cyclometalated RuII anthraquinone complexes were found to exhibit strong anticancer activity in hypoxic cancer cells through multiple synergistic pathways (see figure).
Url:
DOI: 10.1002/chem.201502154
Affiliations:
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Six novel ruthenium(II) anthraquinone complexes were designed and synthesized; they exhibit similar or superior cytotoxicity compared to cisplatin in hypoxic HeLa, A549, and multidrug‐resistant (A549R) tumor cell lines. Their anticancer activities are related to their lipophilicity and cellular uptake; therefore, these physicochemical properties of the complexes can be changed by modifying the ligands to obtain better anticancer candidates. Complex 1, the most potent member of the series, is highly active against hypoxic HeLa cancer cells (IC50=0.53 μM). This complex likely has 46‐fold better activity than cisplatin (IC50=24.62 μM) in HeLa cells. This complex tends to accumulate in the mitochondria and the nucleus of hypoxic HeLa cells. Further mechanistic studies show that complex 1 induced cell apoptosis during hypoxia through multiple pathways, including those of DNA damage, mitochondrial dysfunction, and the inhibition of DNA replication and HIF‐1α expression, making it an outstanding candidate for further in vivo studies.</div><div type="abstract" xml:lang="en">Simply the best: The cytotoxicities of RuII complexes are consistent with their hydrophobicity and cellular uptake properties. Cyclometalated RuII anthraquinone complexes were found to exhibit strong anticancer activity in hypoxic cancer cells through multiple synergistic pathways (see figure).</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Zeng, Leli" sort="Zeng, Leli" uniqKey="Zeng L" first="Leli" last="Zeng">Leli Zeng</name></noRegion><name sortKey="Chao, Hui" sort="Chao, Hui" uniqKey="Chao H" first="Hui" last="Chao">Hui Chao</name><name sortKey="Chao, Hui" sort="Chao, Hui" uniqKey="Chao H" first="Hui" last="Chao">Hui Chao</name><name sortKey="Chao, Hui" sort="Chao, Hui" uniqKey="Chao H" first="Hui" last="Chao">Hui Chao</name><name sortKey="Chen, Yu" sort="Chen, Yu" uniqKey="Chen Y" first="Yu" last="Chen">Yu Chen</name><name sortKey="Huang, Huaiyi" sort="Huang, Huaiyi" uniqKey="Huang H" first="Huaiyi" last="Huang">Huaiyi Huang</name><name sortKey="Ji, Liangnian" sort="Ji, Liangnian" uniqKey="Ji L" first="Liangnian" last="Ji">Liangnian Ji</name><name sortKey="Wang, Jinquan" sort="Wang, Jinquan" uniqKey="Wang J" first="Jinquan" last="Wang">Jinquan Wang</name><name sortKey="Zhao, Donglei" sort="Zhao, Donglei" uniqKey="Zhao D" first="Donglei" last="Zhao">Donglei Zhao</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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